A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome.

@article{Boonstra2010ARO,
  title={A review of statistical methods for testing genetic anticipation: looking for an answer in Lynch syndrome.},
  author={Philip S. Boonstra and Stephen B. Gruber and Victoria M Raymond and S Huang and Susanne Timshel and Mef Nilbert and Bhramar Mukherjee},
  journal={Genetic epidemiology},
  year={2010},
  volume={34 7},
  pages={756-68}
}
Anticipation, manifested through decreasing age of onset or increased severity in successive generations, has been noted in several genetic diseases. Statistical methods for genetic anticipation range from a simple use of the paired t-test for age of onset restricted to affected parent-child pairs to a recently proposed random effects model which includes extended pedigree data and unaffected family members [Larsen et al., 2009]. A naive use of the paired t-test is biased for the simple reason… CONTINUE READING
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