A review of selected candidate endophenotypes for depression.

  title={A review of selected candidate endophenotypes for depression.},
  author={Brandon L. Goldstein and Daniel N. Klein},
  journal={Clinical psychology review},
  volume={34 5},
Endophenotypes are proposed to occupy an intermediate position in the pathway between genotype and phenotype in genetically complex disorders such as depression. To be considered an endophenotype, a construct must meet a set of criteria proposed by Gottesman and Gould (2003). In this qualitative review, we summarize evidence for each criterion for several putative endophenotypes for depression: neuroticism, morning cortisol, frontal asymmetry of cortical electrical activity, reward learning… CONTINUE READING
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