A review of pulmonary arterial hypertension: role of ambrisentan

  title={A review of pulmonary arterial hypertension: role of ambrisentan},
  author={Robyn J. Barst},
  journal={Vascular Health and Risk Management},
  pages={11 - 22}
Pulmonary arterial hypertension (PAH) is a rare fatal disease. Current disease-specific therapeutic interventions in PAH target 1 of 3 established pathways in disease pathobiology: prostacyclin, nitric oxide, and endothelin-1. Endothelin receptor antagonists (ERAs) act on the endothelin pathway by blocking binding of endothelin-1 to its receptors (endothelin type-A [ET(A)] and/or type-B [ET(B)]) on the surface of endothelial and smooth muscle cells. Ambrisentan is an oral, once-daily, ET(A… CONTINUE READING


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