A review of probiotics studies in HIV research suggests improved immunological presentation and preservation of viral host restrictive factors of TH17 in HIV patients

Abstract

Background Recovery of gut mucosal immune system is slow and incomplete during HAART therapy, leading to elevated inflammation rates, increased mitochondrial damage and the pathogenesis of replicatively competent escape mutations. A recent study of Ganeden BC30, Bacillus coagulans GBI-30, demonstrated safety, increased CD4+ counts in patients on HARRT, and a significant increase in CD69 and maturation of dendritic cells in vitro. Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 demonstrate efficacy in treating naïve HIV patients against gastrointestinal and urogenital infections . Restoration of viral host restrictive factors of Th17 cell lines in GALT may prevent the evolving viral diversity, provoking increased CD4 presentation and regulation of inflammatory cytokine levels responsible for increased viral replication.

DOI: 10.1186/1742-4690-9-S1-P22

Extracted Key Phrases

Cite this paper

@inproceedings{Selbovitz2012ARO, title={A review of probiotics studies in HIV research suggests improved immunological presentation and preservation of viral host restrictive factors of TH17 in HIV patients}, author={M Selbovitz and Keller and R A Miller and Moore and Farmer and Bray}, booktitle={Retrovirology}, year={2012} }