A review of perchloroethylene and rat mononuclear cell leukemia.

  title={A review of perchloroethylene and rat mononuclear cell leukemia.},
  author={John Ishmael and Paul H Dugard},
  journal={Regulatory toxicology and pharmacology : RTP},
  volume={45 2},
Mononuclear cell leukemia (MNCL) is an extremely common spontaneous disease of ageing F344 rats accompanied by splenomegaly, anemia, thrombocytopenia, and leukemic infiltration (initially of the spleen, liver, and lung). Rare in other rat strains, incidence in F344 rats is variable, has been increasing, and can exceed 70% in controls. MNCL cells possess natural killer (NK) cell characteristics and apparently, the neoplastic cells derive from large granular lymphocytes (LGL), hence the… CONTINUE READING
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