A review of nicotinamide: treatment of skin diseases and potential side effects

@article{Rolfe2014ARO,
  title={A review of nicotinamide: treatment of skin diseases and potential side effects},
  author={Heidi M Rolfe},
  journal={Journal of Cosmetic Dermatology},
  year={2014},
  volume={13}
}
  • H. Rolfe
  • Published 1 December 2014
  • Biology, Medicine
  • Journal of Cosmetic Dermatology
Nicotinamide, also known as niacinamide, is the amide form of vitamin B3. It is a precursor of essential coenzymes for numerous reactions in the body including adenosine triphosphate (ATP) production. Nicotinic acid, also known as niacin, is converted into nicotinamide in the body. The use of topical nicotinamide in the treatment of acne vulgaris; melasma; atopic dermatitis; rosacea; and oral nicotinamide in preventing nonmelanoma skin cancer is discussed. The possible side effects and… 

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Extended randomized, double-blind, placebo-controlled trials with long-term follow-up periods are needed to assess the efficacy and safety of nicotinamide as a whitening agent.

Potential effects of the combination of nicotinamide, vitamin B2 and vitamin C on oxidative-mediated hepatotoxicity induced by thioacetamide

This work demonstrates that NA, VB2, and VC cross-talk with each other that act as a more potent biochemical chain of antioxidant defense against TAA-induced toxicities in vivo.

Clinical Evidence for Targeting NAD Therapeutically

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REVIEWING THE THERAPEUTIC COMBINATION OF MULTIVITAMINS

This review presents all the studies conducted to prove the therapeutic effects of vitamins and proves the effectiveness of combination therapies of vitamins with other medication for treatment of various diseases.

Effects of Black Vinegar and Niacinamide on LPS-Induced Inflammation on Human Keratinocytes

It is concluded that BA and niacinamide have effective anti-inflammatory properties in HaCaT cells and may be used as new alternative treatments for inflammatory skin diseases.

Perspectives of topical formulations for melasma.

It is important that prescribers and researchers evaluate the best cost-benefit ratio of topical therapeutic options and develop new formulations, enabling efficacy in the treatment with safety and comfort during application, through the reduction of adverse effects.
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References

SHOWING 1-10 OF 39 REFERENCES

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The literature on nicotinamide is reviewed for a number of cosmeceutical applications, such as improvement of dispigmentation and reduction in rhytids, as well as improvement in blotchiness and erythema.

Hepatic toxicity from large doses of vitamin B3 (nicotinamide).

The following case demonstrates that nicotinamide may cause major hepatic injury and is associated with abnormalities of liver function when used in large doses in the treatment of hypercholesterolemia.

Case reports: new onset flushing due to unauthorized substitution of niacin for nicotinamide.

A patient with rosacea is reported who developed new onset flushing due to unauthorized substitution of niacin for nicotinamide, which is a well-known and often dose-limiting side effect of niakin therapy.

Safety of high-dose nicotinamide: a review

Experience to date suggests that the ratio of risk to benefit of long-term nicotinamide treatment would be highly favourable, should the drug prove efficacious in diabetes prevention, and high-dose Nicotinamide should still be considered as a drug with toxic potential at adult doses in excess of 3 gm/day and unsupervised use should be discouraged.

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Nicotinamide protects isolated islets in vitro from the toxicity of a number of agents, but only in doses that produce significant PARP inhibition, and increased intracellular levels of NAD.

Topical application of 1‐methylnicotinamide in the treatment of rosacea: a pilot study

Results indicate that MNA+ might be a useful agent for treating rosacea, and a metabolite of nicotinamide, 1‐methylnicotinamide (MNA+), has anti‐inflammatory properties.

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  • T. Fukushima
  • Biology
    Environmental health and preventive medicine
  • 2005
It is hypothesized that niacin is a causal substance in the development of Parkinson’s disease through the following processes: NAD produced from niacIn releases nicotinamide via poly(ADP-ribosyl)ation, activated by the hydroxyl radical, and methylated to 1-methylnicotinamide (MNA) in the cytoplasm.

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  • W. Gehring
  • Chemistry, Medicine
    Journal of cosmetic dermatology
  • 2004
Nicotinic acid and niacinamide are similarly effective as a vitamin because they can be converted into each other within the organism.