A review of nicotinamide: treatment of skin diseases and potential side effects

  title={A review of nicotinamide: treatment of skin diseases and potential side effects},
  author={Heidi M Rolfe},
  journal={Journal of Cosmetic Dermatology},
  • Heidi M Rolfe
  • Published 1 December 2014
  • Biology, Medicine
  • Journal of Cosmetic Dermatology
Nicotinamide, also known as niacinamide, is the amide form of vitamin B3. It is a precursor of essential coenzymes for numerous reactions in the body including adenosine triphosphate (ATP) production. Nicotinic acid, also known as niacin, is converted into nicotinamide in the body. The use of topical nicotinamide in the treatment of acne vulgaris; melasma; atopic dermatitis; rosacea; and oral nicotinamide in preventing nonmelanoma skin cancer is discussed. The possible side effects and… 

Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety

Nicotinamide prevents ultraviolet radiation from reducing ATP levels and inhibiting glycolysis, thus preventing the UV radiation‐induced energy crisis and enhances DNA repair and reduces UV‐induced suppression of immunity.

Nicotinamide: New Indications in Dermatology.

Oral nicotinamide: The role in skin cancer chemoprevention

Efficacy and safety of NAM was evaluated in a Phase III double‐blinded control‐placebo study (ONTRAC), thus demonstrating that the incidence of actinic keratoses and non‐melanoma skin cancers was lower in the nicotinamide group than in placebo group.

Oral nicotinamide for non-melanoma skin cancers: A review

Current evidence is not definitive that oral nicotinamide supplementation reduces the incidence of NMSC, but it constitutes a low-risk management option that may be particularly relevant for high-risk individuals, and should be discussed as an option for these patients.

Nicotinamide as a Skin Whitener: Evidence and Controversies

Extended randomized, double-blind, placebo-controlled trials with long-term follow-up periods are needed to assess the efficacy and safety of nicotinamide as a whitening agent.

Clinical Evidence for Targeting NAD Therapeutically

It is concluded that promising, yet still speculative, results have been reported for the treatment of psoriasis and enhancement of skeletal muscle activity, and further trials are required to determine the optimal method of raising NAD levels, identifying the target conditions, and comparisons to the present standard of care for these conditions.


This review presents all the studies conducted to prove the therapeutic effects of vitamins and proves the effectiveness of combination therapies of vitamins with other medication for treatment of various diseases.

Effects of Black Vinegar and Niacinamide on LPS-Induced Inflammation on Human Keratinocytes

It is concluded that BA and niacinamide have effective anti-inflammatory properties in HaCaT cells and may be used as new alternative treatments for inflammatory skin diseases.

Perspectives of topical formulations for melasma

It is important that prescribers and researchers evaluate the best cost–benefit ratio of topical therapeutic options and develop new formulations, enabling efficacy in the treatment with safety and comfort during application, through the reduction of adverse effects.

Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne.

Key outcomes included participants' global self-assessment of acne improvement (PGA), withdrawal for any reason, minor adverse events, and quality of life, which was mainly long-term for the PGA outcome and mixed length (medium-term mainly) forMinor adverse events.



Nicotinamide in dermatology

The literature on nicotinamide is reviewed for a number of cosmeceutical applications, such as improvement of dispigmentation and reduction in rhytids, as well as improvement in blotchiness and erythema.

Hepatic toxicity from large doses of vitamin B3 (nicotinamide).

The following case demonstrates that nicotinamide may cause major hepatic injury and is associated with abnormalities of liver function when used in large doses in the treatment of hypercholesterolemia.

Case reports: new onset flushing due to unauthorized substitution of niacin for nicotinamide.

A patient with rosacea is reported who developed new onset flushing due to unauthorized substitution of niacin for nicotinamide, which is a well-known and often dose-limiting side effect of niakin therapy.

Safety of high-dose nicotinamide: a review

Experience to date suggests that the ratio of risk to benefit of long-term nicotinamide treatment would be highly favourable, should the drug prove efficacious in diabetes prevention, and high-dose Nicotinamide should still be considered as a drug with toxic potential at adult doses in excess of 3 gm/day and unsupervised use should be discouraged.

Topical application of NADH for the treatment of rosacea and contact dermatitis

It was found that topical application of 1% NADH diluted in Vaseline ointment can be very effective in the treatment of rosacea and contact dermatitis and therapy with NADH can be viewed as a potential alternative to other established treatments.

The Use of Nicotinamide in the Prevention of Type 1 Diabetes

Nicotinamide protects isolated islets in vitro from the toxicity of a number of agents, but only in doses that produce significant PARP inhibition, and increased intracellular levels of NAD.

Topical application of 1‐methylnicotinamide in the treatment of rosacea: a pilot study

Results indicate that MNA+ might be a useful agent for treating rosacea, and a metabolite of nicotinamide, 1‐methylnicotinamide (MNA+), has anti‐inflammatory properties.


Nicotinamide gel provides potent antiinflammatory activity without the risk of inducing bacterial resistance.

Niacin metabolism and Parkinson’s disease

  • T. Fukushima
  • Biology
    Environmental health and preventive medicine
  • 2005
It is hypothesized that niacin is a causal substance in the development of Parkinson’s disease through the following processes: NAD produced from niacIn releases nicotinamide via poly(ADP-ribosyl)ation, activated by the hydroxyl radical, and methylated to 1-methylnicotinamide (MNA) in the cytoplasm.

Nicotinic acid/niacinamide and the skin

  • W. Gehring
  • Chemistry, Medicine
    Journal of cosmetic dermatology
  • 2004
Nicotinic acid and niacinamide are similarly effective as a vitamin because they can be converted into each other within the organism.