A review of neuroimaging studies of young relatives of individuals with schizophrenia: a developmental perspective from schizotaxia to schizophrenia.

@article{Thermenos2013ARO,
  title={A review of neuroimaging studies of young relatives of individuals with schizophrenia: a developmental perspective from schizotaxia to schizophrenia.},
  author={Heidi W. Thermenos and Matcheri S. Keshavan and Richard J Juelich and Elena Molokotos and Susan L. Whitfield-Gabrieli and Benjamin K. Brent and Nikos Makris and Larry J. Seidman},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2013},
  volume={162B 7},
  pages={604-35}
}
In an effort to identify the developing abnormalities preceding psychosis, Dr. Ming T. Tsuang and colleagues at Harvard expanded Meehl's concept of "schizotaxia," and examined brain structure and function in families affected by schizophrenia (SZ). Here, we systematically review genetic (familial) high-risk (HR) studies of SZ using magnetic resonance imaging (MRI), examine how findings inform models of SZ etiology, and suggest directions for future research. Neuroimaging studies of youth at HR… CONTINUE READING
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