A review of morphological techniques for detection of peroxisomal (and mitochondrial) proteins and their corresponding mRNAs during ontogenesis in mice: application to the PEX5-knockout mouse with Zellweger syndrome.

@article{Baumgart2003ARO,
  title={A review of morphological techniques for detection of peroxisomal (and mitochondrial) proteins and their corresponding mRNAs during ontogenesis in mice: application to the PEX5-knockout mouse with Zellweger syndrome.},
  author={Eveline Baumgart and H. Dariush Fahimi and Heike Steininger and Markus Grabenbauer},
  journal={Microscopy research and technique},
  year={2003},
  volume={61 2},
  pages={121-38}
}
In the era of application of molecular biological gene-targeting technology for the generation of knockout mouse models to study human genetic diseases, the availability of highly sensitive and reliable methods for the morphological characterization of the specific phenotypes of these mice is of great importance. In the first part of this report, the role of morphological techniques for studying the biology and pathology of peroxisomes is reviewed, and the techniques established in our… CONTINUE READING

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With the help of these techniques , it is now possible to identify and distinguish unequivocally peroxisomes from mitochondria , two classes of cell organelles giving by light microscopy a punctate staining pattern in microscopical immunohistochemical preparations of paraffin - embedded mouse tissues .
With the help of these techniques , it is now possible to identify and distinguish unequivocally peroxisomes from mitochondria , two classes of cell organelles giving by light microscopy a punctate staining pattern in microscopical immunohistochemical preparations of paraffin - embedded mouse tissues .
With the help of these techniques , it is now possible to identify and distinguish unequivocally peroxisomes from mitochondria , two classes of cell organelles giving by light microscopy a punctate staining pattern in microscopical immunohistochemical preparations of paraffin - embedded mouse tissues .
With the help of these techniques , it is now possible to identify and distinguish unequivocally peroxisomes from mitochondria , two classes of cell organelles giving by light microscopy a punctate staining pattern in microscopical immunohistochemical preparations of paraffin - embedded mouse tissues .
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