A review of metabolic and enzymatic engineering strategies for designing and optimizing performance of microbial cell factories

@inproceedings{Fisher2014ARO,
  title={A review of metabolic and enzymatic engineering strategies for designing and optimizing performance of microbial cell factories},
  author={Amanda K. Fisher and Benjamin G. Freedman and David R. Bevan and Ryan S. Senger},
  booktitle={Computational and structural biotechnology journal},
  year={2014}
}
Microbial cell factories (MCFs) are of considerable interest to convert low value renewable substrates to biofuels and high value chemicals. This review highlights the progress of computational models for the rational design of an MCF to produce a target bio-commodity. In particular, the rational design of an MCF involves: (i) product selection, (ii) de novo biosynthetic pathway identification (i.e., rational, heterologous, or artificial), (iii) MCF chassis selection, (iv) enzyme engineering of… CONTINUE READING
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