A review of major Crohn’s disease susceptibility genes and their role in disease pathogenesis

@article{Barrett2011ARO,
  title={A review of major Crohn’s disease susceptibility genes and their role in disease pathogenesis},
  author={Meghan Barrett and Sathees B.C. Chandra},
  journal={Genes & Genomics},
  year={2011},
  volume={33},
  pages={317-325}
}
Crohn’s disease (CD) is a chronic inflammatory bowel disease whose relevance is increasing in industrialized society. Recent genome wide association studies revealed over seventy one loci associated with disease penetrance. Several variants that increase disease risk encode for altered proteins that diminish bacterial host defense. NOD2 alters intracellular bacterial sensing while ATG16L1 is thought to diminish bacterial clearance by impairing autophagy. Additionally, changes in the IBD5 locus… CONTINUE READING
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