A review of fasting effects on the response of cancer to chemotherapy.

  title={A review of fasting effects on the response of cancer to chemotherapy.},
  author={Mehdi Sadeghian and Sepideh Rahmani and Saman Khalesi and Ehsan Hejazi},
  journal={Clinical nutrition},
The Complementary Role of Exercise and Fasting in the Treatment of Cancer: A Narrative Review of Mechanisms Related to Metabolic Stress Elements
These interventions can be used to improve the cancer-based therapeutic index on individual differences and prevent the complications of the disease and improve the patient’s quality of life.
Short-Term Fasting Synergizes with Solid Cancer Therapy by Boosting Antitumor Immunity
Preclinical and clinical evidence of fasting diets synergizing with cancer therapy by boosting antitumor immunity and alleviating immunosuppression are summarized, as well as the clinical findings reporting the immunomodulatory effects of STF during various cancer treatments, including immunotherapy.
Calorie Restriction for Cancer Prevention and Therapy: Mechanisms, Expectations, and Efficacy
CR has a huge impact on promoting longevity by delaying the severity and the onset of inflammatory and several age-related diseases including obesity, cardiovascular, neurodegenerative and ophthalmic disorders, and cancer.
Strategies to Mitigate Chemotherapy and Radiation Toxicities That Affect Eating
Although the reduction of side effects involves anticipate, reduce, and prevent some toxicities encountered during chemotherapy and radiation, toxicity reduction can be satisfying for not only the patient, but everyone involved in cancer care.
The Clinical Value of Nutritional Care before and during Active Cancer Treatment
The present review discusses about malnutrition and the importance of an early nutritional assessment during chemotherapy and treatment with novel checkpoint inhibitors, in order to prevent treatment-induced toxicities and to improve survival outcomes.
LKB1: Can We Target an Hidden Target? Focus on NSCLC
Interestingly, emerging data highlighted that LKB1 alterations represent positive determinants to the new KRAS specific inhibitors response in KRAS co-mutated NSCLCs, which will give patients a concrete chance to finally benefit from an effective therapy.
Functional Profiling of Head and Neck/Esophageal Squamous Cell Carcinoma to Predict Cetuximab Response.
It is indicated that nutrient modification may enhance cetuximab response in SCC patients, and biomarker results strengthen the hypothesis that dynamic biomarkers can be used to predict patient response to cetUXimab.
Circadian rhythms and cancers: the intrinsic links and therapeutic potentials
In this review, insights are provided into the mechanisms underlying how several types of disruption of the circadian rhythm can drive cancer progression, which may expand the understanding of cancer development from the clock perspective.
Nanodiscs: a versatile nanocarrier platform for cancer diagnosis and treatment.
The recent development of theranostic nanodiscs for cancer mitigation ranging from traditional lipid nanodiscos encased by membrane scaffold proteins to newer nanodISCs where either the membrane scaffolding proteins or the lipid bilayers themselves are replaced with their synthetic analogues.


Effects of short-term fasting on cancer treatment
Preliminary data show that STF is safe, but challenging in cancer patients receiving chemotherapy, and ongoing clinical trials need to unravel if STF can also diminish toxicity and increase efficacy of chemotherapeutic regimes in daily practice.
Enhanced Therapeutic Efficacy in Cancer Patients by Short-term Fasting: The Autophagy Connection
A number of mechanisms by which fasting-induced autophagy may have an impact on therapeutic efficacy in various oncological contexts are reviewed.
Fasting and cancer treatment in humans: A case series report
The cases presented here suggest that fasting in combination with chemotherapy is feasible, safe, and has the potential to ameliorate side effects caused by chemotherapies, but they are not meant to establish practice guidelines for patients undergoing chemotherapy.
The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study
STF during chemotherapy was well tolerated and reduced hematological toxicity of TAC in HER2-negative BC patients, and may reduce a transient increase in, and/or induce a faster recovery of DNA damage in PBMCs after chemotherapy.
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
It is suggested that multiple cycles of fasting promote differential stress sensitization in a wide range of tumors and could potentially replace or augment the efficacy of certain chemotherapy drugs in the treatment of various cancers.
Safety and feasibility of fasting in combination with platinum-based chemotherapy
Fasting for 72 h around chemotherapy administration is safe and feasible for cancer patients and biomarkers such as IGF-1 may facilitate assessment of differences in chemotherapy toxicity in subgroups achieving the physiologic fasting state.
Fasting and Caloric Restriction in Cancer Prevention and Treatment.
  • S. Brandhorst, V. Longo
  • Medicine
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
  • 2016
Preclinical and preliminary clinical studies on dietary restriction and fasting are reviewed and their role in inducing cellular protection and chemotherapy resistance is reviewed, with the potential to be widely used to prevent and treat cancer.
Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study
MSTF during chemotherapy can reduce chemotherapy-induced toxicities and enhance the tolerance of chemotherapy, and the results indicate that mSTF is safe and feasible in gynaecologic cancer patients.
Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models
Fasting cycles enhance gemcitabine effect in vitro and in the in vivo PC xenograft mouse model, suggesting that restrictive dietary interventions could enhance the efficacy of existing cancer treatments in pancreatic cancer patients.