A review of enzyme induction of warfarin metabolism with recommendations for patient management.

@article{Cropp1997ARO,
  title={A review of enzyme induction of warfarin metabolism with recommendations for patient management.},
  author={J S Cropp and Henry I. Bussey},
  journal={Pharmacotherapy},
  year={1997},
  volume={17 5},
  pages={917-28}
}
We conducted a review of literature from the MEDLINE data base (1966-January 1997), and bibliographies of published articles, reviews, and letters to classify enzyme induction of warfarin metabolism interactions by onset, extent, and offset. Ten hepatic microsomal enzyme agents were assessed. Likelihood of interaction was based on the strength of supporting literature. Enzyme induction of warfarin metabolism by rifampin and barbiturates is considered likely, although the characteristics of the… CONTINUE READING
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