A review of drug solubility in human intestinal fluids: implications for the prediction of oral absorption.

@article{Augustijns2014ARO,
  title={A review of drug solubility in human intestinal fluids: implications for the prediction of oral absorption.},
  author={Patrick Augustijns and Benjamin Wuyts and Bart Hens and Pieter Annaert and James M. Butler and Joachim Brouwers},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2014},
  volume={57},
  pages={322-32}
}
The purpose of this paper is to collate all recently published solubility data of orally administered drugs in human intestinal fluids (HIF) that were aspirated from the upper small intestine (duodenum and jejunum). The data set comprises in total 102 solubility values in fasted state HIF and 37 solubility values in fed state HIF, covering 59 different drugs. Despite differences in the protocol for HIF sampling and subsequent handling, this summary of HIF solubilities provides a critical… CONTINUE READING
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Intestinal drug

  • S. Clarysse, J. Brouwers, J. Tack, P. Annaert, P. Augustijns
  • 2011
Highly Influential
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The effects of food on the dissolution of poorly soluble drugs in human and in model small intestinal fluids

  • E. M. Persson, Gustafsson, +7 authors B. Abrahamsson
  • Pharm. Res
  • 2005
Highly Influential
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