A review of drug-induced Leydig cell hyperplasia and neoplasia in the rat and some comparisons with man.

@article{Prentice1995ARO,
  title={A review of drug-induced Leydig cell hyperplasia and neoplasia in the rat and some comparisons with man.},
  author={D. E. Prentice and Alfred Wayne Meikle},
  journal={Human & experimental toxicology},
  year={1995},
  volume={14 7},
  pages={562-72}
}
This paper describes control of normal Leydig cell function and testosterone production. The macroscopic and histopathological appearances of spontaneous Leydig cell hyperplasias and tumors (LCT) in the rat are reviewed together with their incidence and hormonal status. Drugs which induce LCTs in chronic studies are discussed and include busereline, carbamazepine, cimetidine, finasteride, flutamide, gemfibrozil, histrelin, hydralazine, indomethacin, isradipine, lactitol, leuprolide… CONTINUE READING
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