A review of diffusion tensor imaging studies in schizophrenia.

@article{Kubicki2007ARO,
  title={A review of diffusion tensor imaging studies in schizophrenia.},
  author={Marek Kubicki and Robert W. McCarley and Carl-Fredrik Westin and Hae-Jeong Park and Stephan E. Maier and Ron Kikinis and Ferenc A. Jolesz and Martha Elizabeth Shenton},
  journal={Journal of psychiatric research},
  year={2007},
  volume={41 1-2},
  pages={
          15-30
        }
}
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References

SHOWING 1-10 OF 93 REFERENCES
Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study.
TLDR
These findings demonstrate the importance of investigating white matter tracts in vivo in schizophrenia and support the hypothesis of a disruption in the normal pattern of connectivity between temporal and frontal brain regions in schizophrenia.
MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia
TLDR
Co-registered PET scans revealed significantly lower correlation coefficients between metabolic rates in the prefrontal cortex and striatum in patients than in controls, providing convergent evidence for diminished fronto–striatal connectivity in schizophrenia.
Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging.
TLDR
Despite the small sample size, diffusion tensor imaging was powerful enough to yield significant group differences, indicating widespread alteration in brain white matter integrity but not necessarily white matter volume in schizophrenia.
Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study
TLDR
The findings of reduced white matter tract integrity in the left uncinate fasciculus and left arcuate fascicule suggest that there is frontotemporal and frontoparietal structural disconnectivity in schizophrenia.
Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms.
TLDR
Anatomical abnormalities in these schizophrenic patients with marked negative symptoms were most evident in left hemispheric neocortical and limbic regions and related white matter tracts, compatible with models that depict schizophrenia as a supraregional disorder of multiple, distributed brain regions and the axonal connections between them.
Investigating regional white matter in schizophrenia using diffusion tensor imaging
TLDR
The findings suggest that the structural integrity of white matter in these patients was not disrupted, and further studies using DTI in larger samples, improved and standardised methods of data acquisition and analysis are needed.
Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study
MRI study of white matter diffusion anisotropy in schizophrenia
TLDR
The voxelwise method used in the current study can provide the basis for hypothesis-driven research and lower fractional anisotropy was lower for patients in the corpus callosum, left superior temporal gyrus, parahippocampal gyri, middle temporal gyri and deep frontal perigenual region.
Neuropathological abnormalities of the corpus callosum in schizophrenia: a diffusion tensor imaging study
TLDR
The presence of DTI changes in the splenium but not the genu of the corpus callosum suggests that there may be a focal disruption of commisural connectivity in schizophrenia, but these findings do not exclude the possibility of abnormalities in other areas of the Corpus Callosum or other regions of white matter.
Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study
TLDR
The hypothesis that schizophrenia is associated with abnormal white matter integrity of the anterior cingulum is supported by DTI data, which revealed that FA values were decreased in the anteriorcingulum of schizophrenia subjects.
...
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