A review of current treatment strategies for infective endocarditis

  title={A review of current treatment strategies for infective endocarditis},
  author={David Luque Paz and Ines Lakbar and Pierre Tattevin},
  journal={Expert Review of Anti-infective Therapy},
  pages={297 - 307}
ABSTRACT Introduction Infective endocarditis is one of the most difficult-to-treat infectious diseases. Areas covered We restricted this review to the anti-infective treatment of the main bacteria responsible for infective endocarditis, i.e. staphylococci, streptococci, enterococci, and Gram-negative bacilli, including HACEK. Specific topics of major interest in treatment strategy are covered as well, including empirical treatment, oral switch, and treatment duration. We searched in the MEDLINE… 

Current Challenges in the Management of Infective Endocarditis

This review aims to address the changing epidemiology of endocarditis, several recent advances in the understanding of the pathophysiology of Endocarditis-triggered sepsis, new useful diagnostic tools as well as current concepts in the medical and surgical management of this disease.

Infective Endocarditis: New Challenges in a Classic Disease.

The choice of an appropriate treatment for each specific case is complex, both in terms of the selection of the appropriate agent and doses and durations of therapy as well as the possibility of using combined bactericidal antibiotic regimens in the initial phase and finalizing treatment at home in patients with good evolution with outpatient oral or parenteral antimicrobial therapies programs.

Endocarditis in the intensive care unit: an update

The lack of evidence on ICU patients with IE highlights the critical importance of multidisciplinary decision-making and the need for further research.

Real-World Use of Dalbavancin in the Era of Empowerment of Outpatient Antimicrobial Treatment: A Careful Appraisal Beyond Approved Indications Focusing on Unmet Clinical Needs

A critical reappraisal of real-world use of dalbavancin for off-label indications is provided and it is shown that the promising efficacy in challenging scenarios, coupled with the unique pharmacokinetic/pharmacodynamic properties, makes dal BVancin a valuable alternative to daily in-hospital intravenous or outpatient antimicrobial regimens in the treatment of long-term Gram-positive infections.

Risk Factors Associated with Poor Outcome in Patients with Infective Endocarditis: An Italian Single-Center Experience

Procalcitonin values, at EI diagnosis and at 48–72 h after starting antibiotics, are prognostic factors useful for stratifying patient risk, and for setting up a personalized treatment.

Intercostal Muscle Abscesses in Infective Endocarditis Associated With Migratory Deposition of Calcium Pyrophosphate

Careful follow-up is required in patients with IE and intercostal muscle abscesses caused by S. aureus bacteremia, due to the possibility of abscess formation when there is concurrent bloodstream infection.

Molecular Analysis of the Presence of pvl, spa, and mecA Genes and Their Correlation with a Range of Antibiotics in Staphylococcus aureus Collected from Burn Patients

There is an association between mecA gene and resistance to the antibiotics oxacillin, cefoxitin, and erythromycin in methicillin-resistant S. aureus strains.

DDDT_A_313756 3349..3378

Dalbavancin is a novel, long-acting lipoglycopeptide characterized by a long elimination half-life coupled with excellent in vitro activity against multidrug-resistant Gram-positives, which makes dalb Cavancin valuable in the current COVID-19 scenario, in which hospitalization and territorial medicine empowerment are unavoidable.

The Dynamics of Infectious Diseases Associated With Injection Drug Use in Lawrence and Lowell, Massachusetts

Collecting data on other complications associated with injection drug use by public health departments may be important to consider because these complications may serve as input to a sentinel system to trigger early intervention and avert potential outbreaks of HIV.

Amoxicillin-Resistant Streptococci Carriage in the Mouths of Children: A Systematic Review and Meta-Analysis

There is an important prevalence of amoxicillin-resistant strains (AMPC-RS) carriage in the mouths of children and specific attention should be directed to AP in those susceptible to IE.



Oral antibiotic therapy for the treatment of infective endocarditis: a systematic review

The use of oral ciprofloxacin in combination with rifampin for uncomplicated right-sided S. aureus IE in IVDUs is supported by one small clinical trial of relatively good quality and could be considered when conventional IV antibiotic therapy is not possible.

Switch to oral antibiotics in the treatment of infective endocarditis is not associated with increased risk of mortality in non-severely ill patients.

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis

In patients with endocarditis on the left side of the heart who were in stable condition, changing to oral antibiotic treatment was noninferior to continued intravenous antibiotic treatment.

Bacteriological outcome of combination versus single-agent treatment for staphylococcal endocarditis.

In staphylococcal NVE, combination treatment is not superior to monotherapy in sterilizing infected valves, but in PVE combination treatment confers an advantage.

Analysis of the 2015 American and European guidelines for the management of infective endocarditis.

Addition of Rifampin to Standard Therapy for Treatment of Native Valve Infective Endocarditis Caused by Staphylococcus aureus

The results suggest that the potential for hepatotoxicity, drug-drug interactions, and the emergence of resistant S. aureus isolates warrants a careful risk-benefit assessment before adding rifampin to standard antibiotic treatment of native valve S.Aureus IE until further clinical studies are performed.

Rifampin treatment of prosthetic valve endocarditis due to Staphylococcus epidermidis.

Twenty-three patients with prosthetic valve endocarditis caused by methicillin-resistant Staphylococcus epidermidis were studied retrospectively for assessment of the role of rifampin treatment and the rates of cure obtained were similar to those obtained with beta-lactam agents alone.

Antimicrobial treatment of infective endocarditis caused by viridans streptococci highly susceptible to penicillin: historic overview and future considerations.

The path that led to current concepts regarding antimicrobial treatment of endocarditis caused by viridans streptococci highly susceptible to penicillin is presented and there are no predictors of cure that can be used to individualize treatment duration in patients with bacterialendocarditis.

Update on blood culture-negative endocarditis.

Rifampin for Surgically Treated Staphylococcal Infective Endocarditis: A Propensity Score-Adjusted Cohort Study.