A review of current large‐scale mouse knockout efforts

@article{Guan2010ARO,
  title={A review of current large‐scale mouse knockout efforts},
  author={Chunmei Guan and Chao Ye and Xiaomei Yang and Jiangang Gao},
  journal={genesis},
  year={2010},
  volume={48}
}
After the successful completion of the human genome project (HGP), biological research in the postgenome era urgently needs an efficient approach for functional analysis of genes. Utilization of knockout mouse models has been powerful for elucidating the function of genes as well as finding new therapeutic interventions for human diseases. Gene trapping and gene targeting are two independent techniques for making knockout mice from embryonic stem (ES) cells. Gene trapping is high‐throughput… Expand
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