A review of central 5-HT receptors and their function

  title={A review of central 5-HT receptors and their function},
  author={Nicholas M Barnes and Trevor Sharp},
5-ht5A receptors as a therapeutic target.
Identification of one of the least well understood 5‐HT receptors (5‐ht5A) in the spinal cord
  • A. Ramage
  • Biology
    The Journal of comparative neurology
  • 2004
The localization of one of the least well understood 5-HT receptors, the 5-ht5A receptor, in the spinal cord is reported, for the first time, and the authors conclude that these receptors may be involved in central motor control, somatosensory (nociception), and autonomic functions.
Central serotonin2C receptor: from physiology to pathology.
The physiology, pharmacology and anatomical distribution of the 5-HT2C receptors in the CNS will be reviewed, and their potential involvement in the pathophysiology of depression, schizophrenia, Parkinson's disease and drug abuse will be discussed.
The Serotonin-6 Receptor as a Novel Therapeutic Target
Preclinical studies provide support for the use of 5-HT6R ligands as promising medications to treat the cognitive dysfunction associated with Alzheimer's disease, obesity, depression, and anxiety.
5-HT1A receptors and memory


Silent 5-HT A receptor antagonists: utility as research tools and therapeutic agents
The term "silent antagonist' has been introduced to distinguish true 5-HT1A receptor antagonists from partial agonists.
Silent 5-HT1A receptor antagonists: utility as research tools and therapeutic agents.
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
It is evident that in the last decade or so, a vast amount of new information has become available concerning the various 5-HT receptor types and their characteristics, and it is important to rationalise in concert all of the available data from studies involving both operational approaches of the classical pharmacological type and those from molecular and cellular biology.
The 5‐HT1B Receptors
The development of selective 5-HT1B receptor agonists and antagonists will be a key step in defining the physiological role of this receptor site in the brain and periphery of the mouse and rat although it must be realized that these compounds, if they are developed, are unlikely to have functional effects in man since the 5- HT1B recognition site is absent in the human CNS.
[5-Hydroxytryptamine receptors].
  • T. Segawa
  • Biology
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica
  • 1989
Based on a number of pharmacological studies, it seems likely that the mode of action of certain psychotropic drugs is closely related to the activity of central 5-HT receptors.
Novel discriminatory ligands for 5-HT2B receptors
  • G. Baxter
  • Biology, Chemistry
    Behavioural Brain Research
  • 1995
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family.
The results demonstrate that the 5HT1D receptors constitute a heterogeneous family of receptors with distinct intracellular signalling properties and expression patterns, and are a distant relative of all previously identified 5‐HT receptors.
5-HT2 receptor subtypes: a family re-united?