A review of applications of tea tree oil in dermatology

@article{Pazyar2013ARO,
  title={A review of applications of tea tree oil in dermatology},
  author={Nader Pazyar and Reza Yaghoobi and Nooshin Bagherani and Afshin Kazerouni},
  journal={International Journal of Dermatology},
  year={2013},
  volume={52}
}
Tea tree oil (TTO) is an essential oil, steam‐distilled from the Australian native plant, Melaleuca alternifolia. It has a minimum content of terpinen‐4‐ol and a maximum content of 1, 8‐cineole. Terpinen‐4‐ol is a major TTO component which exhibits strong antimicrobial and anti‐inflammatory properties. Tea tree oil exerts antioxidant activity and has been reported to have broad‐spectrum antimicrobial activity against bacterial, viral, fungal, and protozoal infections affecting skin and mucosa… 
Tea tree oil: a promising essential oil
Abstract The use of essential oils (EOs) in the perfumery, agriculture, food industry and cosmetics is quite common owing to their aromatic properties. Tea tree oil is an EO with immense potential
Tea Tree Oil and Its Use in Aromatherapy
TLDR
In this review historical, and morphological information about M. alternifolia plant, chemical properties related to TTO and the mechanism of antimicrobial, antiviral and antifungal actions will be explained, relying extensively on existing literature.
Allergic Contact Dermatitis Due to Tea Tree Oil.
Tea tree oil: contact allergy and chemical composition
TLDR
The clinical picture of allergic contact dermatitis caused by TTO depends on the products used; most reactions are caused by the application of pure oil; cosmetics are the culprits in a minority of cases.
Microsponge Based Gel of Tea Tree Oil for Dermatological Microbial Infections
TLDR
The findings of the study suggest that MS loaded gel could prove alternative to conventional antibacterial formulations for dermatological microbial infections as well as Ethyl Cellulose microsponges as topical carriers for TTO.
DEVELOPMENT AND CHARACTERIZATION OF ANTI-DANDRUFF NIOSOMAL HAIR GEL CONTAINING TEA TREE OIL
TLDR
Niosomal vesicles were selected for tea tree oil delivery because of their penetration enhancing ability and exhibited good stability throughout 90 days at different temperatures and humidity.
The Influence of Tea Tree Oil on Antifungal Activity and Pharmaceutical Characteristics of Pluronic® F-127 Gel Formulations with Ketoconazole
TLDR
The developed gels containing TTO can be considered as favourable formulations in terms of drug release and antifungal activity and were characterized by beneficial bioadhesive properties.
A Case Of Verruca Vulgaris In A Paediatric Patient Treated With Aroma Therapy-Based Korean Medicine By Tea Tree Oil(Melaleuca Alternifolia)
TLDR
This case suggests that Korean medicine, especially aroma therapy using tea tree oil is an effective treatment for Melaleuca Alternifolia.
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References

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TLDR
This work presents a review of tea tree oil with regard to its history, chemistry, purported medicinal uses, and possible adverse cutaneous effects.
A comparative study of tea‐tree oil versus benzoylperoxide in the treatment of acne
TLDR
5% tea‐tree oil and 5% benzoyl peroxide had a significant effect in ameliorating the patients' acne by reducing the number of inflamed and non‐inflamed lesions (open and closed comedones), although the onset of action in the case of tea‐ tree oil was slower.
Melaleuca alternifolia (Tea Tree) Oil: a Review of Antimicrobial and Other Medicinal Properties
TLDR
This review summarizes recent developments in understanding of the antimicrobial and anti-inflammatory activities of the tea tree oil and its components, as well as clinical efficacy.
Tea Tree Oil as a Novel Antipsoriasis Weapon
TLDR
Attention is drawn to the antipsoriatic effect of TTO and a theoretical molecular approach is provided, suggesting that terpinen-4-ol may be a novel potential agent against psoriasis.
A review of the toxicity of Melaleuca alternifolia (tea tree) oil.
Melaleuca alternifolia (tea tree) oil gel (6%) for the treatment of recurrent herpes labialis.
TLDR
The essential oil of Melaleuca alternifolia, or tea tree oil, has broad-spectrum antimicrobial activity in vitro, including activity against herpes simplex virus (HSV), the aetiological agent of RHL.
In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species
TLDR
The data suggest that terpinen-4-ol is a likely mediator of the in vitro and in vivo activity of TTO, and holds promise for the treatment of vaginal candidiasis, and particularly the azole-resistant forms.
Comparison of the cidal activity of tea tree oil and terpinen‐4‐ol against clinical bacterial skin isolates and human fibroblast cells
Aims:   The aim of this study was to compare both the antimicrobial activity of terpinen‐4‐ol and tea tree oil (TTO) against clinical skin isolates of meticillin‐resistant Staphylococcus aureus
Tea tree oil reduces histamine‐induced skin inflammation
Summary Background  Tea tree oil is the essential oil steam‐distilled from Melaleuca alternifolia , an Australian native plant. In recent years it has become increasingly popular as an antimicrobial
Inhibition of acetylcholinesterase by Tea Tree oil
TLDR
Two major constituents of Tea Tree oil, 1,8‐cineole and terpinen‐4‐ol, were shown to inhibit acetylcholinesterase at IC50 values (inhibitor concentrations required to give 50% inhibition) of 0.04 and 10.30 mm, respectively, which supported the hypothesis that the insecticidal activity ofTea Tree oil was attributable, in part, to the anticholinestersterase activity of tea Tree oil.
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