ACE, a carboxypeptidase that hydrolyses angiotensin-1 to angiotensin-2, is widely found in human tissues including vascular endothelium. It is also produced by epithelioid cells of sarcoid granulomata which elevate serum ACE, a useful test of active sarcoidosis, despite its less than optimal sensitivity and specificity. It is not known why ACE production is… (More)
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