A review of PARP inhibitors: from bench to bedside.

@article{Underhill2011ARO,
  title={A review of PARP inhibitors: from bench to bedside.},
  author={Caroline Underhill and Maud Toulmonde and Herv{\'e} R Bonnefoi},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2011},
  volume={22 2},
  pages={
          268-79
        }
}
BACKGROUND Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors, with novel and selective mechanisms of action, have moved from the laboratory to the clinic in just the last few years. DESIGN We conducted an extensive review of PARP inhibitors using a Medline search. We also searched abstracts in databases of major international oncology meetings from the last 4 years. RESULTS To understand the mechanisms of action of PARP inhibitors requires a basic understanding of DNA… CONTINUE READING

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