A review of NMDA receptors and the phencyclidine model of schizophrenia.

@article{Thornberg1996ARO,
  title={A review of NMDA receptors and the phencyclidine model of schizophrenia.},
  author={S A Thornberg and S R Saklad},
  journal={Pharmacotherapy},
  year={1996},
  volume={16 1},
  pages={82-93}
}
Current models of drug-induced psychosis insufficiently describe the symptoms of schizophrenia. Phencyclidine-induced psychosis is a model that more completely reflects the pathophysiology of the disease. By decreasing glutamatergic neurotransmission, phencyclidine decreases gamma-aminobutyric acid release from the nucleus accumbens, striatum, and hippocampus (manifested by MK-801); may inhibit tonic release of dopamine from the nucleus accumbens and striatum, resulting in increased dopamine… CONTINUE READING
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