A review of MRI studies of progressive brain changes in schizophrenia.

@article{Okubo2001ARO,
  title={A review of MRI studies of progressive brain changes in schizophrenia.},
  author={Yukari Okubo and Tomoyuki Saijo and Keiichi Oda},
  journal={Journal of medical and dental sciences},
  year={2001},
  volume={48 3},
  pages={
          61-7
        }
}
In the early twentieth century, when Kraepelin first described ‘dementia praecox’ which eventually evolved into the concept of schizophrenia, he proposed that dementia praecox was probably an unknown organic brain disease. However, in contrast to the case of Alzheimer’s disease and Huntington’s disease, subsequent pathological studies of the brain failed to establish the neuropathology of schizophrenia. As a result, it had been generally accepted that schizophrenia would be a functional… CONTINUE READING