A review of HNS-32: a novel azulene-1-carboxamidine derivative with multiple cardiovascular protective actions.

@article{Tanaka2001ARO,
  title={A review of HNS-32: a novel azulene-1-carboxamidine derivative with multiple cardiovascular protective actions.},
  author={Y. Tanaka and Koki Shigenobu},
  journal={Cardiovascular drug reviews},
  year={2001},
  volume={19 4},
  pages={
          297-312
        }
}
HNS-32 [N(1),N(1)-dimethyl-N(2)-(2-pyridylmethyl)-5-isopropyl-3,8-dimethylazulene-1- carboxamidine] (CAS Registry Number: 186086-10-2) is a newly synthesized azulene derivative. Computer simulation showed that its three dimensional structure is similar to that of the class Ib antiarrhythmic drugs, e.g., lidocaine or mexiletine. HNS-32 potently suppressed ventricular arrhythmias induced by ischemia due to coronary ligation and/or ischemia-reperfusion in dogs and rats. In the isolated dog and… 
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TLDR
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