A reversible monoamine oxidase A inhibitor (moclobemide) facilitates smoking cessation and abstinence in heavy, dependent smokers

@article{Berlin1995ARM,
  title={A reversible monoamine oxidase A inhibitor (moclobemide) facilitates smoking cessation and abstinence in heavy, dependent smokers},
  author={Ivan Berlin and S Sa{\"i}d and Odile Spreux-Varoquaux and Jean Marie Launay and Robert Olivares and V{\'e}ronique Millet and Yves Lecrubier and Alain Jacques Puech},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1995},
  volume={58}
}
To assess the effectiveness of moclobemide on smoking cessation and abstinence in heavy, dependent smokers. There is a strong association between smoking and depression, especially in dependent smokers. It was hypothesized that smoking is a self‐medication to treat depression. Cigarette smoke has monoamine oxidase (MAO)‐inhibitory properties, and smokers have lower MAO activity than nonsmokers. 
Monoamine oxidase and cigarette smoking.
TLDR
Human and animal studies documenting the inhibitory effects of tobacco smoke on MAO are summarized and MAO inhibition in the context of smoking epidemiology, MAO inhibitor compounds in tobacco, reinvestigations of low platelet MAO in psychiatric disorders and smoking cessation are discussed. Expand
Monoamine Oxidase Inhibition for Tobacco Pharmacotherapy
TLDR
The links between smoking and monoamine oxidase (MAO) inhibition are reviewed, which could lead to the development of novel pharmacotherapies to treat tobacco dependence. Expand
Lazabemide, a selective, reversible monoamine oxidase B inhibitor, as an aid to smoking cessation.
TLDR
MAOB inhibitors are promising treatments as an aid in smoking cessation and further studies may associate MAOB inhibitors with nicotine replacement therapies to increase therapeutic efficacy. Expand
Inhibition of monoamine oxidase B in the brains of smokers
TLDR
It is proposed that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking. Expand
Contribution of monoamine oxidase (MAO) inhibition to tobacco and alcohol addiction.
TLDR
It is concluded that the inhibition of MAO by constituents contained in tobacco and tobacco smoke, enhances the addiction induced by tobacco smoking. Expand
Monoamine oxidase and tobacco dependence.
TLDR
A review of the current knowledge of the association between MAO and tobacco dependence is provided and it is suggested that further research into this topic is likely to lead to more effective pharmacotherapies for smoking cessation. Expand
Monoamine oxidases and tobacco smoking.
TLDR
It is speculated that MAO inhibition by compounds found in either tobacco or tobacco smoke can potentiate nicotine's effects and more effective anti-smoking drug strategies may be developed. Expand
A selective reversible monoamine oxidase B inhibitor in smoking cessation: effects on its own and in association with transdermal nicotine patch
TLDR
The selective, reversible MAO-B inhibitor EVT302 was not superior to placebo in helping smokers quit, in line with data with selegiline and confirms that MAO -B inhibitors are not effective in smoking cessation. Expand
Non-nicotinic therapies for smoking cessation.
TLDR
Promising new therapeutic products are emerging and they will provide smokers additional options to assist in achieving smoking cessation andhibitors of nicotine metabolism are also promising candidates for smoking reduction and cessation. Expand
Brain monoamine oxidase A inhibition in cigarette smokers.
  • J. Fowler, N. Volkow, +8 authors A. Wolf
  • Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1996
TLDR
The results show that tobacco smoke exposure is associated with a marked reduction in brain MAO A, and this reduction is about half of that produced by a brief treatment with tranylcypromine, suggesting thatMAO A inhibition needs to be considered as a potential contributing variable in the high rate of smoking in depression and in the development of more effective strategies for smoking cessation. Expand
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References

SHOWING 1-10 OF 52 REFERENCES
Monoamine oxidase A and B activities in heavy smokers
TLDR
It is concluded that the activities of both forms of the MAO are reduced in heavy dependent smokers. Expand
Clonidine, depression, and smoking cessation.
TLDR
If this trend continues, the population of smokers will be almost exclusively smokers who are highly dependent on nicotine in ten to 20 years, according to the realization that smoking is a dependence disorder. Expand
Platelet monoamine oxidase activity and cigarette smoking.
TLDR
MAO activity was significantly lower for female smokers than for female non-smokers and for males, and it is possible that smoking causes inhibition of MAO by a direct effect or by indirect effects such as altering hormone levels. Expand
Irreversible inhibition of monoamine oxidase by some components of cigarette smoke.
TLDR
The irreversible inhibition of MAO by cigarette smoke may well be related to the low platelet MAO associated with cigarette smokers as previously reported and the implication of such cigarette smoke-caused reduction ofMAO activity in relation to Parkinsonism is discussed. Expand
Low platelet monoamine oxidase activity in cigarette smokers.
TLDR
The activity of platelet monoamine oxidase was found to be significantly lower in normal female subjects who smoked at least 5 cigarettes per day than in non-smokers, a finding that may be related to both smoking and to low MAO activity. Expand
Smoking cessation, clonidine, and vulnerability to nicotine among dependent smokers
This study examines the efficacy of clonidine in smoking cessation and the influence of gender, history of major depression, and measures of nicotine dependence.
Platelet monoamine oxidase: Low activity in cigarette smokers
TLDR
The data suggest that smoking directly or indirectly reduced platelet MAO activity and plasma thiocyanate concentrations. Expand
Do serotonin uptake inhibitors decrease smoking? Observations in a group of heavy drinkers.
TLDR
Zimelidine and citalopram effects on ethanol intake and smoking behavior were evaluated to exclude with 99.99% confidence the possibility that these drugs decrease smoking behavior by 50%. Expand
A Placebo‐controlled study of three clonidine doses for smoking cessation
TLDR
This study investigated the lower end of the effective dose range of clonidine for smoking cessation to identify the lowest useful dose and thus minimize the adverse effects of the drug. Expand
Serotonin and monoamine oxidase in mouse skin: effects of cigarette smoke exposure.
TLDR
Serotonin concentration increased as a function of the frequency of exposure, while serotonin uptake by the skin was maximally increased after two 8 min exposures, and MAO activity for serotonin, but not for tyramine, was decreased by cigarette smoke exposure of more than 8 min. Expand
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