A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

@article{Niki2011ARF,
  title={A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis},
  author={Ivana Niki{\'c} and Doron Merkler and Catherine Diamante Sorbara and Mary T Brinkoetter and Mario Kreutzfeldt and Florence Martine Bareyre and Wolfgang Br{\"u}ck and Derron L. Bishop and Thomas Misgeld and Martin Kerschensteiner},
  journal={Nature Medicine},
  year={2011},
  volume={17},
  pages={495-499}
}
In multiple sclerosis, a common inflammatory disease of the central nervous system, immune-mediated axon damage is responsible for permanent neurological deficits. How axon damage is initiated is not known. Here we use in vivo imaging to identify a previously undescribed variant of axon damage in a mouse model of multiple sclerosis. This process, termed 'focal axonal degeneration' (FAD), is characterized by sequential stages, beginning with focal swellings and progressing to axon fragmentation… CONTINUE READING
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