A reverse transcriptase/maturase promotes splicing by binding at its own coding segment in a group II intron RNA.

@article{Wank1999ART,
  title={A reverse transcriptase/maturase promotes splicing by binding at its own coding segment in a group II intron RNA.},
  author={Herbert Wank and Joseph Sanfilippo and Ravindra N. Singh and Manabu Matsuura and Alan M. Lambowitz},
  journal={Molecular cell},
  year={1999},
  volume={4 2},
  pages={239-50}
}
Group II introns encode reverse transcriptases that promote RNA splicing (maturase activity) and then with the excised intron form a DNA endonuclease that mediates intron mobility by target DNA-primed reverse transcription (TPRT). Here, we show that the primary binding site for the maturase (LtrA) encoded by the Lactococcus lactis Ll.LtrB intron is within a region of intron domain IV that includes the start codon of the LtrA ORF. This binding is enhanced by other elements, particularly domain I… CONTINUE READING
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