A reversal of fortune: practical problems in the monitoring and interpretation of an EORTC breast cancer trial.

@article{Sylvester1994ARO,
  title={A reversal of fortune: practical problems in the monitoring and interpretation of an EORTC breast cancer trial.},
  author={Richard Joel Sylvester and Harry Bartelink and Robert D. Rubens},
  journal={Statistics in medicine},
  year={1994},
  volume={13 13-14},
  pages={1329-35}
}
An example of some of the practical problems associated with the interim monitoring of accumulating time to event data is illustrated through an EORTC clinical trial in locally advanced breast cancer which studied the effects of both hormonal therapy and chemotherapy using a 2 x 2 factorial design. The data monitoring process is described and summaries of… CONTINUE READING