A retrospective immunohistochemical study reveals atypical scrapie has existed in the United Kingdom since at least 1987.

@article{Webb2009ARI,
  title={A retrospective immunohistochemical study reveals atypical scrapie has existed in the United Kingdom since at least 1987.},
  author={Paul R. Webb and Linda Powell and Margaret Denyer and Sarah Marsh and Colin A Weaver and Marion M Simmons and Elizabeth M. Johns and John Sheehan and Peter Horsfield and Chris Lyth and Christina Wilson and Ann Long and Saira Cawthraw and Ginny C Saunders and Yvonne I. Spencer},
  journal={Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc},
  year={2009},
  volume={21 6},
  pages={826-9}
}
Atypical scrapie is a relatively recent discovery, and it was unknown whether it was a new phenomenon or whether it had existed undetected in the United Kingdom national flock. Before 1998, the routine statutory diagnosis of transmissible spongiform encephalopathy (TSE) in sheep relied on the presence of TSE vacuolation in the brainstem. This method would not have been effective for the detection of atypical scrapie. Currently, immunohistochemistry (IHC) and Western blot are commonly used for… CONTINUE READING

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