A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at high risk of myelosuppression.

@article{Murphy2002ARE,
  title={A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at high risk of myelosuppression.},
  author={L. P. Murphy and David P Atherton},
  journal={The British journal of dermatology},
  year={2002},
  volume={147 2},
  pages={308-15}
}
BACKGROUND Atopic eczema is a chronic inflammatory skin disease, which in most children can be adequately controlled using topical therapy. However, in a small number of children it is necessary to use systemic treatments to gain an acceptable level of disease control. OBJECTIVES To evaluate azathioprine as a treatment for severe atopic eczema in children, and the value of pretreatment thiopurine methyltransferase (TPMT) levels in the identification of patients at high risk of… CONTINUE READING

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