A retro-inverso peptide corresponding to the GH loop of foot-and-mouth disease virus elicits high levels of long-lasting protective neutralizing antibodies.

@article{Briand1997ARP,
  title={A retro-inverso peptide corresponding to the GH loop of foot-and-mouth disease virus elicits high levels of long-lasting protective neutralizing antibodies.},
  author={J P Briand and N K Benkirane and Gilles Guichard and J. F. E. Newman and Marc H. V. Van Regenmortel and Fred L. Brown and Sylviane Muller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 23},
  pages={12545-50}
}
Peptides corresponding to the immunodominant loop located at residues 135-158 on capsid protein VP1 of foot-and-mouth disease virus (FMDV) generally elicit high levels of anti-peptide and virus-neutralizing antibodies. In some instances, however, the level of neutralizing antibodies is low or even negligible, even though the level of anti-peptide antibodies is high. We have shown previously that the antigenic activity of peptide 141-159 of VP1 of a variant of serotype A can be mimicked by a… CONTINUE READING