A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

@inproceedings{Lippmann2014ARA,
  title={A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources},
  author={Ethan S Lippmann and Abraham Jacob Al-Ahmad and Samira M Azarin and Sean P Palecek and Eric V Shusta},
  booktitle={Scientific reports},
  year={2014}
}
Blood-brain barrier (BBB) models are often used to investigate BBB function and screen brain-penetrating therapeutics, but it has been difficult to construct a human model that possesses an optimal BBB phenotype and is readily scalable. To address this challenge, we developed a human in vitro BBB model comprising brain microvascular endothelial cells (BMECs), pericytes, astrocytes and neurons derived from renewable cell sources. First, retinoic acid (RA) was used to substantially enhance BBB… CONTINUE READING
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