A retinoic acid--rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(+) T cells.

@article{Guo2012ARA,
  title={A retinoic acid--rich tumor microenvironment provides clonal survival cues for tumor-specific CD8(+) T cells.},
  author={Yanxia Guo and Karina Pino-Lagos and Cory Ahonen and Kathy D. Bennett and Jinshan Wang and Joseph L. Napoli and Rune Blomhoff and Shanthini Sockanathan and Roshantha A. S. Chandraratna and Ethan Dmitrovsky and Mary Jo Turk and Randolph J. Noelle},
  journal={Cancer research},
  year={2012},
  volume={72 20},
  pages={
          5230-9
        }
}
While vitamin A has been implicated in host resistance to infectious disease, little is known about the role of vitamin A and its active metabolite, retinoic acid (RA) in host defenses against cancer. Here, we show that local RA production within the tumor microenvironment (TME) is increased up to 5-fold as compared with naïve surrounding tissue, with a commensurate increase in RA signaling to regionally infiltrating tumor-reactive T cells. Conditional disruption of RA signaling in CD8(+) T… CONTINUE READING

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