A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability

@article{Woitach1998ARP,
  title={A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability},
  author={Joseph T. Woitach and Minghuang Zhang and C H Niu and Snorri Thorgeirsson},
  journal={Nature Genetics},
  year={1998},
  volume={19},
  pages={371-374}
}
The retinoblastoma (RB) gene is one of the most extensively studied tumour-suppressor genes. Deletion or inactivation of both RB alleles is an essential, rate-limiting step in the formation of retinoblastoma and osteosarcoma that arise in families that carry mutant RB (ref. 2). RB inactivation is also found in other human tumours. Whereas loss of RB function is associated with the loss of cellular proliferative control, introduction of a wild-type RB can suppress cell growth and tumorigenicity… Expand
Retinoblastoma protein partners.
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The goal of this review is to summarize the current literature of pRb-associated proteins and to raise several important questions, including how many functions does pRB possess, which of these functions are important for development, and which contribute to tumor suppression. Expand
Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas
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The results demonstrate the importance of ubiquitin–proteasome pathway in the regulation of cell growth and oncogenic transformation, and indicate that gankyrin overexpression contributes to hepatocarcinogenesis by destabilizing RB1. Expand
Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo.
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This work studied the effects of acute and chronic low dose radiation exposure on the induction of RBBP9 and RB signaling pathway in vivo in mouse spleen and found that R BBP9 played a pivotal role in IR responses in vivo. Expand
Structure-function analysis of the retinoblastoma tumor suppressor protein – is the whole a sum of its parts?
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  • Medicine, Biology
  • Cell Division
  • 2007
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This review will focus on literature that investigates pRB by isolating functions based on binding sites within the pocket domain and the prospects for using this approach to further explore the unknown functions of pRB. Expand
Differential Roles for the Retinoblastoma Protein in Cycling and Quiescent Neural Populations
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It is reported that Rb regulates the expression of neogenin, a gene encoding a receptor involved in cell migration and axon guidance, and it is demonstrated that regulation of neogensin expression is required for neural precursor migration. Expand
Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein
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It is suggested that LXCXE-dependent interactions are not essential for pRb to exert growth arrest, and directly targeting HDAC2 to E2F responsive promoters as an E 2F/HDAC hybrid protein failed to effect cell cycle arrest. Expand
Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers.
TLDR
Structural- function studies of RBBP9 suggest possible routes for novel cancer drug discovery programs and sequence analysis suggests that R BBP9 belongs to the α/β hydrolase superfamily of enzymes. Expand
RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia
TLDR
Retinoblastoma-binding protein 9 (RBBP9) is identified as a tumor-associated serine hydrolase that displays elevated activity in pancreatic carcinomas, and a previously uncharacterized serineHydrolase activity associated with epithelial neoplasia is defined, demonstrating the potential benefit of functional proteomics in the identification of new therapeutic targets. Expand
Assignment1 of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1–H1 and human chromosome 20p11.2 by fluorescence in situ hybridization
TLDR
A rat cDNA encoding a novel protein called Bog is isolated from a rat liver epithelial cell line and the Bog gene was mapped to mouse chromosome 2G1–H1 and to human chromosome 20p11.2 to gain insight into the possible relationship with the transformed phenotype in other cell types. Expand
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TLDR
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References

SHOWING 1-10 OF 29 REFERENCES
The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells.
TLDR
The concept that the RB gene acts as both a growth and tumor suppressor in bladder cancer cells is supported, using an RB expression plasmid transfected into the bladder carcinoma cell line HTB9. Expand
Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.
TLDR
It is suggested that RB inactivation can play a significant role in the genesis of a common adult neoplasm and that restoration of normal RB-encoded protein in tumors could have clinical utility. Expand
Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.
TLDR
Analysis of polyclonal anti-synthetic peptide serum indicates that inactivation of the RB protein, p105-Rb, is universal in retinoblastoma cells, vindicating the predictions of the Knudson "two-hit" hypothesis. Expand
Inactivation of the retinoblastoma susceptibility gene in human breast cancers.
TLDR
The retinoblastoma susceptibility gene is shown to be inactivated in two of nine human breast cancer cell lines examined, significant in relation to proposed genetic mechanisms of breast cancer formation. Expand
Retinoblastoma gene deletions in human glioblastomas.
TLDR
Examination of a group of benign and malignant gliomas for evidence of structural alterations of the retinoblastoma susceptibility gene suggests that RB gene abnormalities may contribute to the development of glioblastomas. Expand
Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells.
TLDR
This demonstration of suppression of the neoplastic phenotype by a single gene provides direct evidence for an essential role of the RB gene in tumorigenesis. Expand
The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle
TLDR
Neither co-injection of RB with a T antigen peptide nor injection into cells expressing T antigen prevents cells from progressing into S phase, which supports the hypothesis that T antigen binding has functional consequences for RB. Expand
Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation
TLDR
TGF- beta 1 and RB appear to function in a common growth-inhibitory pathway in which TGF-beta 1 acts to retain RB in the underphosphorylated, growth-suppressive state. Expand
Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.
TLDR
The results strongly suggest that inactivation of the RB gene might be involved in the development of lung cancers, especially of SCCs. Expand
Identification of a growth suppression domain within the retinoblastoma gene product.
TLDR
When full-length RB and certain truncated forms were synthesized in human RB -/- cells, it was found that the minimal region necessary for overt growth suppression extended from residue 379 to 928, and a functional pocket domain and sequences extending from the carboxy-terminal boundary of the pocket to theCarboxyl terminus of the protein were both necessary for growth suppression. Expand
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