A restriction fragment length polymorphism results in a nonconservative amino acid substitution encoded within the first exon of the human lysyl oxidase gene.

@article{Csiszr1993ARF,
  title={A restriction fragment length polymorphism results in a nonconservative amino acid substitution encoded within the first exon of the human lysyl oxidase gene.},
  author={Katalin Csisz{\'a}r and Thomas J. Mariani and J S Gosin and Susan B. Deak and Charles D. Boyd},
  journal={Genomics},
  year={1993},
  volume={16 2},
  pages={401-6}
}
A cDNA covering most of the coding sequence for human lysyl oxidase was used to screen, by Southern blot analysis, genomic DNA from circulating lymphocytes obtained from unrelated, apparently normal individuals. A heritable restriction fragment length polymorphism (RFLP) within a PstI restriction site was detected in 36% of individuals screened (a total of 72 chromosomes were analyzed). The major allele was represented as a 1.7-kb PstI restriction fragment. The minor allele was detected as 1.4… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-4 of 4 extracted citations

Interaction of collagen-related genes and susceptibility to betel quid-induced oral submucous fibrosis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2002

Similar Papers

Loading similar papers…