A restriction endonuclease analysis of the bacterial plasmid controlling the ecoRI restriction and modification of DNA.

@article{Betlach1976ARE,
  title={A restriction endonuclease analysis of the bacterial plasmid controlling the ecoRI restriction and modification of DNA.},
  author={Mary Betlach and V Hershfield and L P Chow and Ward Brown and Heather Goodman and Herbert W. Boyer},
  journal={Federation proceedings},
  year={1976},
  volume={35 9},
  pages={2037-43}
}
Genetic analyses of DNA restriction and modification mechanisms have been encumbered by the inability to rigorously select for mutant phenotypes associated with these systems. The application of restriction endonucleases has now proved to be a successful approach to the genetic analyses of small genomes that are recalcitrant to the more standard genetic techniques. Restriction endonucleases EcoRI and HindIII were used to analyze the structure of the plasmid genome responsible for the EcoRI… CONTINUE READING

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