A restricted cell population propagates glioblastoma growth after chemotherapy

@inproceedings{Chen2012ARC,
  title={A restricted cell population propagates glioblastoma growth after chemotherapy},
  author={Jian Ye Chen and Yanjiao Li and Tzong-Shiue Yu and Ren{\'e}e M. McKay and Dennis K. Burns and Steven G Kernie and Luis F Parada},
  year={2012}
}
Glioblastoma multiforme is the most common primary malignant brain tumour, with a median survival of about one year. This poor prognosis is due to therapeutic resistance and tumour recurrence after surgical removal. Precisely how recurrence occurs is unknown. Using a genetically engineered mouse model of glioma, here we identify a subset of endogenous tumour cells that are the source of new tumour cells after the drug temozolomide (TMZ) is administered to transiently arrest tumour growth. A… CONTINUE READING

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