A resting-state functional MRI study on the effect of vagal nerve stimulation on spontaneous regional brain activity in drug-resistant epilepsy patients

  title={A resting-state functional MRI study on the effect of vagal nerve stimulation on spontaneous regional brain activity in drug-resistant epilepsy patients},
  author={Jin Zhu and Cuiping Xu and Xi Zhang and Liang Qiao and Xueyuan Wang and Xiaohua Zhang and Xiao-ming Yan and Duanyu Ni and Tao Yu and Guojun Zhang and Yongjie Li},
  journal={Behavioural Brain Research},

Prediction of the Responsiveness to Vagus-Nerve Stimulation in Patients with Drug-Resistant Epilepsy via Directed-Transfer-Function Analysis of Their Perioperative Scalp EEGs

It is demonstrated that the presurgical DTF profiles of responders were different from those of nonresponders, and a presurgical normal DTF profile may predict good responsiveness to VNS.

A systematic review of magnetic resonance imaging in patients with an implanted vagus nerve stimulation system

Cranial MRI of patients with an implanted VNS Therapy System can be completed satisfactorily and is tolerable and safe using 1.5 T and 3 T MRI scanners when performed in adherence to the VNS manufacturer’s guidelines.

Vagus nerve stimulation for conservative therapy-refractive epilepsy and depression.

The evaluation of the numerous iVNS trials of the past two decades showed multiple positive effects on other immunological, cardiological, and gastroenterological diseases so that additional therapy indications may be expected depending on future study results.

Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms



Disrupted local neural activity and functional connectivity in subjective tinnitus patients: evidence from resting-state fMRI study

ST patients had altered regional neural activity and inter-regional connectivity in partial auditory and non-auditory brain regions, mainly involving the default mode network and audio-visual network, which could further improve the understanding of the neuroimaging mechanism in ST.

Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study

The significant findings of this study revealed an important role for the cerebellum in motor control and cognitive regulation in JME patients, which also have an effect on the activity of the occipital lobe.

Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient

A hypothesis based on this single case study that VNS acts on intractable epilepsy by modulating the balance between salience and default-mode networks through the integral hub of the anterior cingulate cortex is proposed.

Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsy

Increased thalamic synaptic activities probably mediate some antiseizure effects of VNS, and future studies should examine neurotransmitter-receptor alterations in reticular and specific thalamus and cerebellum nuclei during VNS.

Abnormal Spontaneous Regional Brain Activity in Young Patients With Anorexia Nervosa.

Children with epilepsy demonstrate macro- and microstructural changes in the thalamus, putamen, and amygdala

Children with epilepsy show statistically significant differences in volume, diffusion, and cerebral blood flow within their thalamus, putamen, and amygdala, suggesting that epilepsy is associated with structural changes of the central nervous system influencing brain development and potentially leading to poorer neurocognitive outcomes.