A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor.


In gamma-aminobutyric acid type A (GABA(A)) receptors, the structural elements that couple ligand binding to channel opening remain poorly defined. Here, site-directed mutagenesis was used to determine if Loop 9 on the non-GABA binding site interface of the beta2-subunit may be involved in GABA(A) receptor activation. Specifically, residues Gly(170)-Gln(185… (More)
DOI: 10.1074/jbc.M109.050294


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