A residue close to α1 loop F disrupts modulation of GABAA receptors by benzodiazepines while their binding is maintained.

@article{Baur2010ARC,
  title={A residue close to α1 loop F disrupts modulation of GABAA receptors by benzodiazepines while their binding is maintained.},
  author={Roland Baur and Benjamin P. L{\"u}scher and Lars Richter and Erwin Sigel},
  journal={Journal of neurochemistry},
  year={2010},
  volume={115 6},
  pages={1478-85}
}
Benzodiazepines act at the major isoforms of GABA type A receptors where they potentiate the current evoked by the agonist GABA. The underlying mechanism of this potentiation is poorly understood, but hypothesized to be related to the mechanism that links agonist binding to channel opening in these ligand activated ion channels. The loop F of the α(1) and… CONTINUE READING