A requirement of STAT3 DNA binding precludes Th-1 immunostimulatory gene expression by NF-κB in tumors.

@article{Lee2011ARO,
  title={A requirement of STAT3 DNA binding precludes Th-1 immunostimulatory gene expression by NF-κB in tumors.},
  author={Heehyoung Lee and Jiehui Deng and Hong Xin and Yong Liu and Drew Mark Pardoll and Hua Yu},
  journal={Cancer research},
  year={2011},
  volume={71 11},
  pages={3772-80}
}
Both STAT3 and NF-κB are persistently activated in diverse cancers and promote tumor cell proliferation, survival, angiogenesis, and metastasis through transcriptional activation of multiple common genes. Paradoxically, STAT3 also suppresses many NF-κB-inducible genes involved in innate and adaptive antitumor immunity in spite of elevated levels of NF-κB in tumors. In this study, we show that expression of many NF-κB downstream target genes in tumors depends on STAT3 DNA binding. When STAT3 is… CONTINUE READING
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STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

  • H Lee, J Deng, +4 authors M Kortylewski
  • Nat Med
  • 2010
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