A requirement for copper in angiogenesis.

@article{Harris2004ARF,
  title={A requirement for copper in angiogenesis.},
  author={Edward D. Harris},
  journal={Nutrition reviews},
  year={2004},
  volume={62 2},
  pages={
          60-4
        }
}
  • E. D. Harris
  • Published 1 February 2004
  • Biology, Medicine
  • Nutrition reviews
Although two decades have passed since copper was shown to stimulate blood vessel formation in the avascular cornea of rabbits, only recently have clinical trials established that Cu privation by diet or by Cu chelators diminishes a tumor's ability to mount an angiogenic response. These data have shed new light on the functional role of Cu in microvessel development and, of equal importance, stimulated new nutritional models of cancer therapeutic intervention. 
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A BRIEF COMMUNICATION
TLDR
It is demonstrated that VEGF is critically involved in copper inhibition of cell hypertrophy induced by hydrogen peroxide in the H9c2 cells, and copper addition at 5 lM in cultures suppressed cellhypertrophy.
Role of Copper and Vascular Endothelial Growth Factor (VEGF) on Endometrial Angiogenesis
TLDR
A brief introduction into the basics of blood vessel development as well as the regulatory mechanisms of this process are discussed and the role of copper ions in angiogenesis is discussed.
High-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent
TLDR
PSP-2 exhibits significant bioactivity at concentrations as low as 5 μM, rendering it a promising anti-angiogenic agent.
Interactive effects of homocysteine and copper on angiogenesis in porcine isolated saphenous vein.
Nanoparticles of Copper Stimulate Angiogenesis at Systemic and Molecular Level
TLDR
The present study indicated for the first time that NanoCu have pro-angiogenic properties at the systemic level, to a greater degree than CuSO4 salt.
Bioinorganic aspects of angiogenesis.
TLDR
The bioinorganic aspects of angiogenesis are described which contribute to a better understanding of the molecular mechanisms and regulation ofAngiogenesis and the role of metals, especially copper, metalloproteinases, and the current status on the imaging of ang iogenesis targeting V EGF or VEGF receptors are discussed.
CTR1 Silencing Inhibits Angiogenesis by Limiting Copper Entry into Endothelial Cells
TLDR
The designed CTR1 siRNA (si 1) when topically applied inhibited angiogenesis and can be further developed for therapeutic application.
Angiogenic Biomarkers of Dysfunctional Uterine Bleeding
TLDR
Under hypoxic conditions, Hypoxia inducible factor 1 alpha rapidly accumulates and activates angiogenic growth factors, receptors and extracellular proteases such as matrix metalloproteinases (MMPs) like MMP-9.
Copper in tumors and the use of copper-based compounds in cancer treatment.
The vascular endothelium as a target of cadmium toxicity.
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TLDR
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The objective of this work was to contribute to the interpretation of the mechanisms of capillary formation in the adult tissues. We have observed that the heparin-copper complex is angiogenic in…
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TLDR
The data are interpreted to indicate that copper ions are involved in the sequence of events leading to angiogenesis and that the carrier molecules may be of quite a different nature.
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TLDR
In the tumor, copper deposits correlated well with its angiogenic and metastatic ability, but additional factors would be required for the process to be induced.
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TLDR
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TLDR
The experiments are interpreted to indicate that angiogenesis is the end result of a sequence of events, two of which are PGE1 production and copper mobilization in the tissue where neovascularization occurs.
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TLDR
It is suggested that copper, a modulator of angiogenesis in vivo, may be involved in the regulation of the biological activity ofAngiogenin.
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TLDR
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TLDR
Specific degradation of SPARC, a matrix-associated protein expressed by endothelial cells during vascular remodeling, releases a bioactive peptide or peptides, containing the sequence (K)GHK, that could regulate angiogenesis in vivo.
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TLDR
First evidence showing that inducible VEGF expression is sensitive to copper is presented and that the angiogenic potential of copper may be harnessed to accelerate dermal wound contraction and closure is presented.
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