A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint.

@article{Wang2004ARF,
  title={A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint.},
  author={R F Wang and Hongtao Yu and Chu-xia Deng},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 49},
  pages={17108-13}
}
BRCA1-associated breast cancer exhibits significantly higher levels of chromosomal abnormalities than sporadic breast cancers. However, the molecular mechanisms regarding the roles of BRCA1 in maintaining genome integrity remain elusive. By using a mouse model deficient for Brca1 full-length isoform (Brca1(Delta11/Delta11)), we found that Brca1(Delta11/Delta11) cells displayed decreased expression of a number of genes that are involved in the spindle checkpoint, including Mad2, which is a key… CONTINUE READING

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