A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos

@article{Drechsel1997ARF,
  title={A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos},
  author={David N. Drechsel and Anthony A. Hyman and Alan Hall and Michael Glotzer},
  journal={Current Biology},
  year={1997},
  volume={7},
  pages={12-23}
}

Figures and Tables from this paper

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Dissecting the role of Rho-mediated signaling in contractile ring formation.
TLDR
This study shows that Rho serves as a microtubule-dependent signal that specifies the position of the contractile ring and bundles microtubules direct Rho-mediated signaling molecules to the furrowing site and regulate furrow formation.
Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac
TLDR
The identification and analysis of a novel Drosophila gene, sticky (sti), essential for cytokinesis in all fly proliferating tissues and opposite genetic interactions with Rho and Rac genes suggest that these GTPases antagonistically regulate STICKY functions.
Regulation of cytokinesis by Rho GTPase flux
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It is proposed that the GAP domain of MgcRacGAP has two unexpected roles throughout cytokinesis: first, it transiently anchors active Rho, and second, it promotes local Rho inactivation, resulting in the constant flux of Rho through the GTPase cycle.
Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells
TLDR
The molecular mechanisms regulating the spatial and temporal activation of RhoA and Cdc42 during mitosis are reviewed, and how this is critical for mitotic progression and completion are reviewed.
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It is found that eggs prevented from cleaving by treatment with antimitotic drugs undergo a sequence of periodic surface contraction waves timed with the cleavage cycle in untreated eggs, suggesting to us that a biological clock exists in the cytoplasm or cortex of vertebrate eggs, which may be involved in timing the cell cycle.
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TLDR
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