A reprogrammable mouse strain from gene-targeted embryonic stem cells

@article{Stadtfeld2010ARM,
  title={A reprogrammable mouse strain from gene-targeted embryonic stem cells},
  author={Matthias Stadtfeld and Nimet Maherali and Marti Borkent and Konrad Hochedlinger},
  journal={Nature Methods},
  year={2010},
  volume={7},
  pages={53-55}
}
The derivation of induced pluripotent stem cells (iPSCs) usually involves the viral introduction of reprogramming factors into somatic cells. Here we used gene targeting to generate a mouse strain with a single copy of an inducible, polycistronic reprogramming cassette, allowing for the induction of pluripotency in various somatic cell types. As these 'reprogrammable mice' can be easily bred, they are a useful tool to study the mechanisms underlying cellular reprogramming. 

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