A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor.

@article{GrootKormelink1998ARM,
  title={A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor.},
  author={Paul J. Groot-Kormelink and Walter H. M. L. Luyten and David Colquhoun and Lucia G Sivilotti},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 25},
  pages={15317-20}
}
We have investigated whether the neuronal nicotinic subunit beta3 can participate in the assembly of functional recombinant receptors. Although beta3 is expressed in several areas of the central nervous system, it does not form functional receptors when expressed heterologously together with an alpha or another beta nicotinic subunit. We inserted into the human beta3 subunit a reporter mutation (V273T), which, if incorporated into a functional receptor, would be expected to increase its agonist… CONTINUE READING

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Perspectives in Hormone Receptor Classification (Black

  • D. Colquhoun
  • 1987

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