A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.

@article{Wang2014ARM,
  title={A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation.},
  author={Hongsheng Wang and Ming De Yan and Jiafang Sun and Shweta Jain and Ryusuke Yoshimi and Sanaz Momben Abolfath and Keiko Ozato and William G. Coleman and Ashley P Ng and Donald Metcalf and Ladina Dirago and Stephen L Nutt and Herbert C. Morse},
  journal={Journal of immunology},
  year={2014},
  volume={193 4},
  pages={1766-77}
}
The IFN regulatory factor family member 8 (IRF8) regulates differentiation of lymphoid and myeloid lineage cells by promoting or suppressing lineage-specific genes. How IRF8 promotes hematopoietic progenitors to commit to one lineage while preventing the development of alternative lineages is not known. In this study, we report an IRF8-EGFP fusion protein reporter mouse that revealed previously unrecognized patterns of IRF8 expression. Differentiation of hematopoietic stem cells into… CONTINUE READING
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