A report of fulminant malignant hyperthermia in a patient with a novel mutation of the CACNA1S gene.

@article{Toppin2010ARO,
  title={A report of fulminant malignant hyperthermia in a patient with a novel mutation of the CACNA1S gene.},
  author={Patrick Jason Toppin and Tony Thomson Chandy and Anand Ghanekar and Natalia Kraeva and William Scott Beattie and Sheila Riazi},
  journal={Canadian journal of anaesthesia = Journal canadien d'anesthesie},
  year={2010},
  volume={57 7},
  pages={689-93}
}
PURPOSE To report the identification of a novel mutation in the CACNA1S gene that encodes the alpha-1-subunit (Cav1.1) of the voltage-gated skeletal muscle L-type calcium channel in a patient with malignant hyperthermia. CLINICAL FINDINGS An otherwise healthy 34-yr-old female developed fulminant malignant hyperthermia (MH) under sevoflurane anesthesia during laparoscopic donor nephrectomy. The first sign was an increase in end-tidal CO(2). Malignant hyperthermia was suspected early, and… CONTINUE READING