A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia

@article{Fujimoto2008ARS,
  title={A replication study confirmed the EDAR gene to be a major contributor to population differentiation regarding head hair thickness in Asia},
  author={Akihiro Fujimoto and Jun Ohashi and Nao Nishida and Taku Miyagawa and Yasuyuki Morishita and Tatsuhiko Tsunoda and Ryosuke Kimura and Katsushi Tokunaga},
  journal={Human Genetics},
  year={2008},
  volume={124},
  pages={179-185}
}
Hair morphology is a highly divergent phenotype among human populations. [] Key Method In this study, we examined the association of 1540T/C with hair morphology in a Japanese population (Northeast Asian). As observed in our previous study, 1540T/C showed a significant association with hair cross-sectional area (P = 2.7 × 10−6) in Japanese. When all populations (Thai-Mai, Indonesian, and Japanese) were combined, the association of 1540T/C was stronger (P = 3.8 × 10−10) than those of age, sex, and population…
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It is concluded that EDAR is a major genetic determinant of Asian hair thickness and the 1540C allele spread through Asian populations due to recent positive selection.
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TLDR
Evidence is presented that a derived nonsynonymous substitution (370A) in EDAR, a gene involved in ectodermal development, was driven to high frequency in East Asia by positive selection prior to 10,000 years ago.
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