A replication silencer element in a plus-strand RNA virus.

  title={A replication silencer element in a plus-strand RNA virus.},
  author={Judit Pogany and Marc R Fabian and K. Andrew White and Peter D Nagy},
  journal={The EMBO journal},
  volume={22 20},
Replication represents a key step in the infectious cycles of RNA viruses. Here we describe a regulatory RNA element, termed replication silencer, that can down-regulate complementary RNA synthesis of a positive-strand RNA virus via an RNA-RNA interaction. This interaction occurs between the 5-nucleotide-long, internally positioned replication silencer and the extreme 3'-terminus of the viral RNA comprising part of the minimal minus-strand initiation promoter. Analysis of RNA synthesis in vitro… CONTINUE READING